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Tuesday, 30 October 2012
How tumors exploit gut flora to fuel growth, and the surprising finding that chemotherapy boosts resistant cancer
S.O.T.T: 'The association between chronic inflammation and tumor development has long been known from the early work of German pathologist Rudolph Virchow. Harvard University pathologist Harold Dvorak later compared tumors with 'wounds that never heal,' noting the similarities between normal inflammation processes that characterize wound- healing and tumorigenesis or tumor-formation. Indeed, 15 to 20 percent of all cancers are preceded by chronic inflammation - a persistent immune response that can target both diseased and healthy tissues... Still, most cancers are not preceded by chronic inflammation. On the other hand, they exploit ubiquitous, infiltrating immune cells to unduly provoke and hijack the host inflammatory reaction. Until now, the mechanism of so-called 'tumor-elicited inflammation,' which is detected in most solid malignancies, was poorly explained...read more>>>...