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Tuesday 11 April 2023

The mRNA platform: What it is, what it means

Back in the spring of 2020 we learned that Operation Warp Speed was hard at work creating a vaccine faster than one had ever been created before. From the decades-long history of vaccine development, we knew that vaccines took 5 to 10 years to make. The subsequent clinical trials could take longer.

How was this possible? When did this scientific leap take place? What was this fantastic new technology that would make such rapid development a reality?

We quickly learned that the new vaccine would use something called mRNA technology. And there were several companies ready to make it happen.

The way mRNA works is not like the way any vaccine worked before. Formerly, vaccines were created by taking a weakened or dead form of the virus and injecting that into humans. The human body would create antibodies to fight and beat the weakened virus, thus giving the body the instructions to create antibodies against it if the full force virus were to ever attack. The individual was immune.

This is not what mRNA does.

The CDC literally changed the definition of vaccine so that mRNA fit the category. We saw this happen two years ago, comparing old and new versions of what they posted on their website.

Here was the definition on the CDC website in 2020:

Vaccines contain the same germs that cause disease . . . But they have been killed or weakened to the point that they don't make you sick. The new version became much more general, to include mRNA.  

Here is the current definition on the CDC website:

A preparation that is used to stimulate the body's immune response against diseases.

The first question you may ask is "Why would the CDC want to make it seem like this is just a standard old familiar technology? Why do they feel like they have to call it a vaccine? Are they trying to trick us into feeling comfortable? Why?"

mRNA is not a traditional vaccine, but it's not new either. It is actually a thirty-year-old technology. You might remember there used to be this thing called "gene therapy" that no one talks about anymore. That's what category this belongs to.

The original purpose of gene therapy was to give people the ability to have their own bodies produce something that they weren't producing naturally, something that their bodies needed, like insulin for diabetics. The purpose was to make up for a deficiency that the body could not generate on its own.

The way it works is that an mRNA strand is constructed by using the genetic code of the thing you want to make. In turn, the mRNA strand that is generated in this way has all the instructions necessary to generate the protein you want.

But the technology had limitations. One thing that was noticed in the first few years of gene therapy is that it didn't work for long. Multiple doses had to be supplied, and the conditions in the body had to be right.

Although this use of mRNA as a therapeutic has been around for decades, with some good and some disappointing results, having the mRNA create an antigen was brand new. Never before were a human's own cells hijacked to create something that is supposed to attack the body.

Suddenly, the technology went from a therapeutic to treat a minority of individuals with particular deficiencies to a drug that everyone in the entire world would take to combat a virus.

When the mRNA Covid vaccine is injected into a person, it moves to the cells and creates the portion of the virus known as the spike protein, the active part of the virus that causes all the harm. The body reacts and fights it off. It's a biological Trojan Horse.

So why would anyone expect this to work like a traditional vaccine, one that bestows immunity for many years, often a lifetime? We have already seen that this method often does not. Didn't the companies selling these drugs as a vaccine and the FDA know this from the beginning?

Another limitation of using this technology as a vaccine is that the immune response becomes tuned to the particulars of that virus. If the virus mutates to a variant, the antibody response is not likely to work against it. The spike protein is slightly different.

This is a very old idea in virology, called original antigenic sin. Basically, your body gets tuned to the variant that you are fighting, and can't see new ones as well. Didn't the companies selling these drugs as a vaccine and the FDA know this from the beginning?

Boosters, anyone?

So they already knew that the mRNA vaccine wouldn't give you lasting immunity and probably wouldn't work against variants. Not only that, they also had no idea of side effects, because they had never used this technology to create an antigen....<<<Read More>>>...