Published in the Journal of Cliinical Investigation and titled, Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways, researchers addressed a common perception (or misperception) in the cancer research community regarding sugar's relationship to cancer: namely, "increased glycolysis [sugar based metabolis] is frequently viewed as a consequence of oncogenic events that drive malignant cell growth and survival." Contrary to this conventional view, the new study "provide[s] evidence that increased glycolytic activation itself can be an oncogenic event..." That is to say, the activation of sugar-based metabolism in a cell - driven by both the presence of increased quantities of glucose and the increase glucose receptors on the cell membrane surface (i.e. "overexpression of a glucose transporter") - drives cancer initiation.
Moreover, the study found that "Conversely, forced reduction of glucose uptake by breast cancer cells led to phenotypic reversion." In other words, interfering with sugar availability and uptake to the cell causes the cancer cell to REVERSE towards its pre-cancer structure-function (phenotype).
What this new research indicates is that sugar - of which Americans consume an astounding 160 lbs annually (imagine: 31 five-pound bags for each of us!) - is one of the primary causes of metabolic cell changes in the body consistent with the initiation and promotion of cancer. And, the research indicates that removing it from the diet, and depriving the cells of it, could REVERSE cancer...read more>>>...
