When we mess up our circadian rhythms through environmental circadian disruption like shift work, jet lag or sleep deprivation,
it's possible that it's impacting our muscle clocks and metabolism. If
that's happening and we are combining this with an unhealthy diet, this
might make it more likely for us to develop glucose intolerance and
diabetes," said Clara Peek, Ph.D., assistant professor of Biochemistry
and Molecular Genetics and of Medicine in the Division of Endocrinology,
Metabolism and Molecular Medicine, who was senior author of the study.
The body's natural circadian clock is comprised of proteins called transcription factors that are present throughout the body, including muscle tissue. The clock synchronizes physical and behavioral changes to the external environment during the 24-hour light cycle.
Disruptions in circadian rhythm have previously been associated
with the development of metabolic diseases, but the contributions of the
skeletal muscle clock have remained elusive....<<<
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