In "Long-term use of melatonin supplements to support sleep may have negative health effects", they took electronic records and highlighted those who were taking melatonin, correlating with heart failure.
Mind you, if you're in heart failure, you'll have insomnia because you can't sleep due to your symptoms. So you'll need to take something. If you don't have heart failure, you sleep better and hence don't require anything. Correlation doesn't equal causation, making this another case of the firefighters getting blamed for the fire.
Melatonin doesn't require a prescription in the U.S., hence it is over-the-counter, and this alone could bias the results significantly. This is called cherry-picking data to create your own reality in discordance with objective reality.
If people want to stop taking melatonin based on this abstract, so be it.
From actual peer reviewed and published studies, here are some of the benefits people would be missing:
The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle. Melatonin has been shown to possess anti-oxidant activity and neuroprotective properties. Melatonin has been shown to have cardioprotective activity in multiple animal and human studies. In short, it's the one thing that is natural and has proven to be beneficial in cardiovascular disease.
Studies have demonstrated that melatonin has significant effects on ischemia-reperfusion injury, myocardial chronic intermittent hypoxia injury, pulmonary hypertension, hypertension, valvular heart diseases, vascular diseases, and lipid metabolism. As an inexpensive and well tolerated drug, melatonin may be a new therapeutic option for cardiovascular disease. ....<<<Read More>>>...
