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General secretary Peter Watt's departure marks another low point for Mr Brown, who had already suffered his worst week since taking power from Tony Blair in June.
The loss of millions of child benefit records, the ongoing Northern Rock crisis and attacks from former army chiefs have left the administration reeling.
And the latest opinion poll published today by The Independent put the Tories 13 points in front - its biggest lead for nearly 20 years and enough to secure a 64-seat Commons majority. (Sky News)