"I really believe [whoever took her] gave her a drug," she said. "There is no way they carried her out of there without her wakening. If she was taken when she was sleeping by somebody she did not know she would have screamed the place down. My son and Kate would never even slap their child, never mind do anything to harm her," she said.
"They are running away from nobody because they are innocent."
Mrs McCann went on to rubbish the police investigation, including DNA evidence reportedly found in Kate and Gerry's hire car which has become the centre of the investigation.
"The thing is that little Amelie is wearing Madeleine's sandals and she is in and out of the car," she said. "Cuddly toys are in it. Madeleine's toys are in it. Madeleine's tops are in it that Amelie is wearing. It's nonsense."
It has also emerged that Mr and Mrs McCann are conducting a secret investigation which they hope will clear them by Christmas. Their legal team has carried out its own interviews with every witness they can find to the events of May 3. They will use the resulting evidence to demolish any accusations that the McCanns were involved in their four-yearold daughter's disappearance. The lawyers will give their defence dossier directly to prosecutor Luis Bilro Verao.They hope that Mr Verao will compare their evidence alongside that gathered by the Algarve police, and throw out the case. A friend of the McCanns revealed that the couple are convinced they will soon be in the clear.
The friend said: "(The lawyers) will make a direct approach to the Portuguese prosecutor's office. They will say, 'This is what we have got. We advise you not to go any further'."