Madeleine's mother has already distributed the posters in shops around Praia da Luz, the Portuguese resort where she went missing. Kate McCann said: "Gerry and I want to remind people that our lovely little girl, Madeleine, is still missing."
The McCanns are hopeful that the new poster campaign will help in their search for Madeleine.
The McCanns travelled along the main motorway between southern Portugal and Spain, which some believe could have been the route taken by Madeleine's abductor. The couple are also visiting the cathedral in Huelva to pray for their daughter's safe return.
Madeleine's parents have taken their campaign to Spain before, as well as Italy, Germany, the Netherlands and Morocco. (Sky News)